In pharmacology, the term ceiling effect refers to a dose-enhancing property of a given drug to have a gradual diminishing effect (eg, lessening). Opioid agonist mixtures of antagonists, such as nalbuphine, serve as a classic example of the effect of the ceiling; increasing the dose of narcotics often leads to smaller and smaller results in pain relief. In many cases, the severity of side effects from drugs increases with increasing doses, long after the therapy ceiling has been reached.
The term is defined as "a phenomenon in which the drug achieves maximum effect, so increasing the dose of the drug does not increase its effectiveness." Sometimes drugs can not be compared in different treatment situations because one drug has a ceiling effect.
Sometimes the desired effect increases with the dose, but the side effects worsen or start becoming dangerous, and the risk to increase in ratio increases. This is because the occupation of all receptors in a given specimen.
Video Ceiling effect (pharmacology)
See also
- Opioid agonist-antagonist
- Buprenorfin
- Codeine
- The dose-response relationship
- Stairway pain
- Weber-Fechner's Law
Maps Ceiling effect (pharmacology)
References
External links
- Is there a ceiling effect from transdermal buprenorphine? Preliminary data on cancer patients
- Clinical evidence for LH ceiling effects induced by recombinant human LH administration during the final follicular phase of the cycle stimulated in type I and II anovulation World Health Organization
- The analgesic effect of i.v. paracetamol: possible effects of paracetamol ceiling on postoperative pain
Source of the article : Wikipedia
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